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Acute myeloid leuke...
Acute myeloid leukemia and clonal chromosome aberrations in relation to past exposure to organic solvents
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- Albin, Maria (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Björk, Jonas (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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Welinder, H (author)
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Tinnerberg, H (author)
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Mauritzson, N (author)
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Johansson, B (author)
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Billstrom, R (author)
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Stromberg, U (author)
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Mikoczy, Z (author)
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Ahlgren, T (author)
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Nilsson, P G (author)
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Mitelman, F (author)
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Hagmar, L (author)
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Scandinavian Journal of Work, Environment and Health. - 0355-3140. ; 26:6, s. 482-491
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
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- OBJECTIVES: The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes. METHODS: Consecutively diagnosed cases of AML (N=333) and 1 population referent per case were retrospectively included in the study. Information on worktasks, companies, and leisure-time activities was obtained with telephone interviews. Exposure probability and intensity were assessed by occupational hygienists. Associations were evaluated with logistic regression. RESULTS: Exposure to organic solvents was associated with an increased risk of AML [low exposure: OR 1.5 (95% confidence interval (95% CI) 1.0-2.3, moderate-high exposure: OR 2.3 (95% CI 1.0-5.0)]. For exposure to solvents, but not to benzene, the OR was 1.2 (95% CI 0.69-2.0) for "low" and 2.7 (95% CI 1.0-7.3) for "moderate-high" exposure. The observed effects increased with intensity and duration of exposure. The estimated effects were higher for patients >60 years of age at the time of diagnosis. The effect of exposure to organic solvents was not differential with regard to morphology [except possibly erythroleukemia: OR 4.2, 95% CI 1.0-17 or the presence of CCA in general]. No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher risk was found for AML with trisomy 8 (OR 11, 95% CI 2.7-42) as the sole aberration. CONCLUSIONS: Exposure to organic solvents was associated with an increased risk of AML. This association was not due to benzene exposure alone and may be modified by age. Furthermore, specific associations with trisomy 8, and possibly also erythroleukemia, were suggested.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- cytogenetic
- case-referent study
- benzene
- age
- effect modification
- erythroleukemia
- occupational limit value
- population attributable risk
- trisomy 8
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Albin, Maria
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Björk, Jonas
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Welinder, H
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Tinnerberg, H
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Mauritzson, N
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Johansson, B
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show more...
-
Billstrom, R
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Stromberg, U
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Mikoczy, Z
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Ahlgren, T
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Nilsson, P G
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Mitelman, F
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Hagmar, L
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Lund University